Background: Studies have been reported that cyclin-dependent kinase5 (CDK5) was associated with the development\nof several cancers. However, the relationship between CDK5 level and clinicopathological factors is still poorly\nunderstood in cervical diseases. The aim of the current study was to investigate the expression of CDK5 and its clinical\nsignificance in variant cervical lesions.\nMethods: Immunohistochemistry (IHC) was used to detect CDK5 expression in 54 cases of chronic cervicitis, 42\ncases of condyloma acuminate (CA), 38 cases of carcinoma in situ, and 360 cases of cervical cancers [adenocarcinoma,\nn = 63; squamous cell carcinoma (SCC), n = 263; adenosquamous carcinoma, n = 34]. The clinicopathological characteristics\nin relation to CDK5 were examined by Pearson�s Chi-square test.\nResults: The positive rates of CDK5 were 27.8, 31.0, 50, 54.0, 58.8, and 62.7 % in chronic cervicitis, CA, carcinoma\nin situ, adenocarcinoma, adenosquamous carcinoma and SCC, respectively. Statistically analysis showed that CDK5\nexpression in cervical cancer tissues was higher than non-cervical cancer tissues (inflammation and CA) (P < 0.001).\nThe overexpression of CDK5 was significantly correlated with lymph node metastasis (r = 0.317; P < 0.001), histological\ntype (r = 0.198; P < 0.001), FIGO stage (r = 0.358; P < 0.001), TNM stage (r = 0.329; P < 0.001) and pathological\ngrade (r = 0.259; P < 0.001) in cervical lesions evaluated by Pearson�s Chi-square test. Furthermore, the positive\nrelationships were found between CDK5 and lymph node metastasis (P < 0.001), FIGO stage (P < 0.001), TNM stage\n(P < 0.001) and pathological grade (P < 0.001) in SCC. CDK5 was positively interrelated to TNM stage (P = 0.017) in\nadenosquamous carcinoma.\nConclusions: CDK5 may play a vital role in the development of cervical cancer, which may be a marker for the diagnosis,\ntherapy and prognosis of cervical cancer.
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